Actovegin injection is a biological drug manufactured from a natural source: it is a calf blood hemodialysate. Its therapeutic benefits stem from a variety of pharmacodynamic actions that can be summarized to a common goal, i.e. the enhancement of cellular metabolism; this results from an insulin-like activity mediated by Inositol-phospho-oligosaccharides. Actovegin® results in beneficial effects in several pathophysiological clinical settings including malfunction of the blood circulation and trophic disturbances in the brain, impairment of peripheral blood circulation and associated diseases, dermal transplants and acute and chronic wounds. Here, we give an overview of the pharmacodynamic actions of calf-blood hemidialysate and its beneficial effects in a variety of clinical settings.
Actovegin reduces the ROS level in blood samples of heart failure patients and diminishes necrosis of SK-N-SH human neuroblastoma cells.
Neurodegenerative disorders of the central nervous system (CNS) are associated with an increased production of hydrogen peroxide (H2O2), which is an inducer of apoptosis in various cell types including CNS. Previously it was shown that actovegin (deproteinized calf blood hemodialysate) reduces neuronal apoptosis, but the mechanism of its protective action is still poorly understood. The effect of actovegin on the apoptosis of SK-N-SH human neuroblastoma cells was studied in the present work. The role of different intracellular signaling pathways involving mitogen-activated protein kinases was analyzed using selective inhibitors. Our data show that the signaling pathways involving p38 MAPK and PI3K play the key role in the protective effect of actovegin against hydrogen peroxide-induced apoptosis in SK-N-SH cells.
Actovegin has three dosage forms. Depending on milligram of active substance on milliliter and number of ampoules it`s supplied in boxes 200mg/5ml – 5 ampoules per box, 80mg/2ml – 25 ampoules per box and 400mg/10ml – 5 ampoules per box.
Actovegin injection ampoules 200mg/5ml #5
This product from is most popular due to moderate concentration of active substance.
Actovegin injection ampoules 80mg/2ml #25
80mg/2ml due to low concentration of active substance is suitable in cases where significant doses are prohibited. Each box contains 25 ampoules.
Actovegin injection ampoules 400mg/10ml #5
This product from is applied when significant dose is needed. Due to high concentration of active substance it must be applied with attention.
See also: Actovegin Prospect